Welcome to the research group DILIS

Data Integration in the Life Sciences

For many problems in the life sciences, different types of data have been generated and provide different views. Each data layer comes with its own limitations, errors and biases, so their integrative analysis is key for robust conclusions in order to understand complex phenomena. Our research group Data Integration in the Life Sciences (DILiS) leverages different methods for data analysis: machine learning enables the detection of patterns from unstructured data, but large deep learning models usually require large amounts of data. Networks allow representing interactions between entities and are highly informative. Straightforwardly, they enable the combined analysis of different data views. Dynamical models capture temporal behaviors and complex, intricate relationships. In addition to using these methods and their strengths separately, we are interested in combining machine learning, network-based analysis and mathematical modeling of dynamic processes. We are thereby especially interested in how the latter two can be used to include prior information (domain knowledge) into the prediction pipelines. Applications stem mainly from a biomedical background, such as drug response prediction, and we focus on integrating different kinds of data with biomolecular, "multi-omics" data.

We at DILiS integrate multi-layered data by combining different analysis methods. Copyright: K. Baum, 2023

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